The Complement Fixation Reaction in Monkey Malaria

Complement Fixation in Human Malaria with an Antigen Prepared from the Monkey Parasite Plasmodium Knowlesi

In the studies of complement fixation described in this paper, the antigens were prepared from (a) normal monkey red cells, (b) parasitized red cells of monkeys dying with Plasmodium knowlesi infection, (c) the spleens of monkeys dying with Plasmodium knowlesi infection; the sera came from (a) normal human beings, (b) patients with syphilis, (c) patients with paresis who were receiving malaria ...

Complement Fixation in Human Malaria Using an Antigen Prepared from the Chicken Parasite Plasmodium Gallinaceum.

The literature concerning various serological reactions in malaria in man has been well reviewed (1). According tothis review, attempts to obtain a specific complement fixation reaction with sera from human beings infected by Plasmodium vivax or by Plasmodium falciparum have led in the past to inconclusive results because no sensitive, specific, and easily standardized antigen was available. Du...

Human Antibodies Fix Complement to Inhibit Plasmodium falciparum Invasion of Erythrocytes and Are Associated with Protection against Malaria

Antibodies play major roles in immunity to malaria; however, a limited understanding of mechanisms mediating protection is a major barrier to vaccine development. We have demonstrated that acquired human anti-malarial antibodies promote complement deposition on the merozoite to mediate inhibition of erythrocyte invasion through C1q fixation and activation of the classical complement pathway. An...

Indirect Complement Fixation in Foot-and-Mouth Disease

Microcomplement-fixation inhibition: a rapid and economical test to detect non-complement-fixing antibodies.

Complement-fixation inhibition test was adapted to the microtiter system. When cat and monkey non-complement-fixing antibody were used, the microtest was shown to be as sensitive as the conventional tube complement-fixation inhibition test.